The Tlatelolco Commitment: A Decade of Action to Achieve Substantive Gender Equality and the Care Society was adopted by the member States of the Economic Commission for Latin America and the Caribbean (ECLAC) at the sixteenth session of the Regional Conference on Women in Latin America and the Caribbean, held in Mexico City in August 2025. It recognizes that the care society proposed by the region is a new paradigm for sustainable development, equality and peace, and that care is a necessity, a human right, a public good, work and a driver of the economy. The agreements are organized around: (i) normative framework, institutional architecture, participation and strengthening of State capacities; (ii) financing and cooperation; (iii) information systems, communication, technology, monitoring, evaluation and accountability. In addition, States reaffirm their commitment to promoting renewed, inclusive and effective multilateralism, and call for the support of the United Nations system in its implementation.